Answers to Quiz 121 · Trigeminal System
The first-order sensory neurons of the trigeminal nerve have their cell bodies in the:
Answer: Semilunar (gasserian) ganglion
The pseudobipolar cells sit in the trigeminal (semilunar or gasserian) ganglion, and each central axon then splits into an ascending and a descending branch. The spinal nucleus is inside the brainstem and holds second-order cells. Revise trigeminal pathway and trigeminal neuralgia
The three divisions of the trigeminal nerve are:
Answer: Ophthalmic, maxillary and mandibular
V1 is ophthalmic, V2 maxillary and V3 mandibular, and each covers one horizontal band of the face. The facial and lingual nerves are separate nerves. Revise trigeminal pathway and trigeminal neuralgia
Which nucleus of the trigeminal nerve is the homologue of the dorsal column nuclei?
Answer: Main sensory nucleus
Main sensory V takes large-diameter fibres from low-threshold mechanoreceptors of face and teeth, just as the dorsal column nuclei do for the body. The spinal nucleus, fed by small pain fibres, is the spinothalamic homologue instead. Revise trigeminal pathway and trigeminal neuralgia
Why is the spinal nucleus of the trigeminal nerve regarded as the spinothalamic pathway of the trigeminal system?
Answer: Its input arrives mainly on small-diameter nociceptive fibres
Small fibres carrying nociception are what the spinal nucleus mainly receives, so the sensation and the fibre type match the spinothalamic system. Large mechanoreceptor fibres go to main sensory V. Revise trigeminal pathway and trigeminal neuralgia
The interpolar subdivision of the spinal nucleus of the trigeminal nerve receives input mainly from:
Answer: Teeth, gums and the lining of the mouth
The middle (interpolar) subdivision takes both mechanosensitive and nociceptive input from teeth, gums and oral mucous membrane. The oral subdivision above it is nociceptive, mainly from the oral cavity. Revise trigeminal pathway and trigeminal neuralgia
Chronic facial pain that no drug will control may be relieved by a surgical lesion of the:
Answer: Caudal subdivision of the spinal nucleus
The caudal subdivision is where most facial nociceptive afferents end, so lesioning it relieves intractable pain. Cutting main sensory V or the lemniscus would take away facial touch instead of, or as well as, the pain. Revise trigeminal pathway and trigeminal neuralgia
Trigeminal fibres reach the thalamus by way of the:
Answer: Trigeminal lemniscus, running alongside the medial lemniscus
Second-order fibres from both trigeminal nuclei cross and ascend as the trigeminal lemniscus, hugging the medial lemniscus. The spinal tract of V is made of first-order descending branches, and no facial fibres pass through the cuneate nucleus. Revise trigeminal pathway and trigeminal neuralgia
The posterior (PO) nucleus of the thalamus receives trigeminal input from the:
Answer: Caudal subdivisions of the spinal nucleus
Caudal spinal V, the most nociceptive part, projects to PO. VPL (VPM in most texts) takes the other two sources, main sensory V and the rostral subdivisions of spinal V. Revise trigeminal pathway and trigeminal neuralgia
Which statement about the trigger zone in trigeminal neuralgia is NOT true?
Answer: It must lie inside the area where the pain is felt
The trigger zone need bear no particular relation to the area in which the pain is perceived: touching the lip can throw the pain into the cheek. The other three statements all describe it correctly. Revise trigeminal pathway and trigeminal neuralgia
A woman of 55 has bursts of stabbing pain in the right cheek, each lasting a few seconds and brought on by lightly touching her upper lip. The usual underlying cause of this condition is:
Answer: Compression of the trigeminal nerve roots
Most patients with trigeminal neuralgia have compressed trigeminal nerve roots; the irritation or degeneration that follows makes the nerve fire episodic bursts of severe pain. Surgical release of the compression is considered when analgesics fail. Revise trigeminal pathway and trigeminal neuralgia
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